Our research group is interested in understanding how RNAs change their structures in order to perform function. Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.
We’re looking for 1–2 motivated postdocs to explore RNA regulation and microRNAs in a supportive, international research environment. If you’re excited about using cutting-edge biophysical and structural biology methods (e.g., NMR, RNA probing, SHAPE) to study RNA function and drug design, we’d love to hear from you. Read more here! Location: Uppsala University Start Date:…
We are excited about two ‘new members’ that have joined our lab. The PromethION 2 Solo is a nanopore (ONP) sequencer which will perform DNA and RNA sequencing for us. And the InsightCell bioreactor will help us to keep cells alive and happy to perform in-cell NMR. This will enable us to study biomolecules in…
We are saying goodbye to Dr. Ting Huang, who worked on miR-based cancer drug design and congratulations on her recently defended her PhD thesis after working with us for five years! Goodbye also to our postdoc David, leaving the lab after evaluating microRNA targeting. Additionally, Eleni is moving on to a new position after working…
Big Congratulations to Dr. Huang who successfully defended her thesis “Design of miR-34a mimics shifting the targetome towards HNF4α” on November 29th with Prof. Kotaro Nakanishi from Ohio State University as her opponent. She systematically identifies mir-34a mutants which more efficiently regulate a subset of the original mir-34a targetome, reducing unwanted off-target effects
Congratulations to Katja and visiting Prof. Christina Thiele for your article in Angewandte Chemie on the interaction dynamics of an enantioselective peptide catalyzed acylation reaction!
We are happy to welcome Eleni to our lab as a new research assistant working on the ribosome project!
Congratulations Rubin and Walter for their publication in NAR studying the previously unseen arrangement of key nucleotides in the human Argonaute 2 miRNA-mRNA complex
Congrats Henry and Reiner for their article in JBNMR on optimising in-cell NMR for nucleic acids!
Visit our News archive
Read more here about available positions
Petzold lab at Uppsala University
Petzold lab at Karolinska Institutet
Department of Medical Biochemistry and Microbiology (IMBIM)
Petzold lab at BMC (D9:3)
Uppsala University
Department of Medical BIochemistry and Microbiology (IMBIM)
Husargatan 3
752 37 Uppsala
Sweden
Katja Petzold
Uppsala University, BMC D9:3
IMBIM
Husargatan 3
752 37 Uppsala
Sweden