Our research group is interested in understanding how RNAs change their structures in order to perform function. Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.
Congratulations Joanna for your contribution in this article in the British Journal of Pharmacology: NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model.
Congratulations Katja for this fantastic achievement! Thank you Uppsala University for this great opportunity, and looking forward working with our new colleagues at IMBIM Department this spring!
After almost 3 years of hard work (and a lot of laugh too) with us, we sadly said Goodbye to Walter who is now pursuing his research adventures on the other side of the globe in The University of Sydney! Wishing you all the best mate!
We are glad to welcome Nicola from Regensburg University and hoping her master project will be in good SHAPE with Joanna’s help!
Katja joins the lab for her masters degree project working with in-cell NMR.
The postdocs Reiner and Julian are now leaving us for new adventures. Wish you all the best!
Description of research group and project: Projects Background: Possibly more than 50% of the human genome codes for non-coding RNA. These RNAs are ubiquitous among all life forms and the mechanisms how non-coding RNAs regulate these cellular functions are largely unknown. Our research group is interested in understanding how RNAs adopt their structures to select…
Congratulations Elnaz, Lorenzo, Walter, Joanna, Ting and Lara for this great team work to see the RABS (RNA:RNA binding by SHAPE ) story out!
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Mail:
Department of Medical Biochemistry and Biophysics (MBB)
Box 23 109 Karolinska Institute SE-104 35
Stockholm, Sweden
Biomedicum:
Petzold Lab Quarter 9B, Dept. of Medical Biochemistry and Biophysics
Solnavägen 9
171 65 Solna
NMR lab:
SciLifeLab Karolinska Institutet
Tomtebodavägen 23b
171 65 Solna