Our research group is interested in understanding how RNAs change their structures in order to perform function. Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.
The new Center of Excellence “Chemical Mechanisms of Life”, headed by 4 research groups including ours, is looking for 4 Postdocs and 1 Research Coordinator. Don’t miss this fantastic opportunity to work with us, and apply now!
Fantastic mechanistic study from David, Elnaz and Walter, to explore the involvement of the 3’-pairing in miRNA targeting processes, is now published in Nucleic Acids Research: Efficient 3′-pairing renders microRNA targeting less sensitive to mRNA seed accessibility
After a few months in the lab, we’d like to thank you both for your contributions in the SHAPE projects. Not always easy to carry on experiments during the lab move to Uppsala but you guys made it! Wishing you the best of luck for your future endeavours!
We are delighted to join Uppsala University and IMBIM department. Thank you everyone for helping with the move and to our new host & neighbours to help us feel like home already. We are all looking forward for this new beginning and hopefully new fruitful collaborations to come!
Congratulations Cagla and Hannes for insights into spider protein and LLPS connections in Journal of the American Chemical Society and a fruitful collaboration: Mass Spectrometry of RNA-Binding Proteins during Liquid–Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures.
Congratulations Joanna for your contribution in this article in the British Journal of Pharmacology: NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model.
Congratulations Katja for this fantastic achievement! Thank you Uppsala University for this great opportunity, and looking forward working with our new colleagues at IMBIM Department this spring!
After almost 3 years of hard work (and a lot of laugh too) with us, we sadly said Goodbye to Walter who is now pursuing his research adventures on the other side of the globe in The University of Sydney! Wishing you all the best mate!
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Department of Medical Biochemistry and Biophysics (MBB)
Box 23 109 Karolinska Institute SE-104 35
Stockholm, Sweden
Biomedicum:
Petzold Lab Quarter 9B, Dept. of Medical Biochemistry and Biophysics
Solnavägen 9
171 65 Solna
NMR lab:
SciLifeLab Karolinska Institutet
Tomtebodavägen 23b
171 65 Solna
Petzold Lab
Dept. of Medical Biochemistry and Microbiology (IMBIM)
D9:3 BMC, Uppsala University
Husargatan 3
752 37 Uppsala