Our research group is interested in understanding how RNAs change their structures in order to perform function. Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.
Big Congratulations to Dr. Huang who successfully defended her thesis “Design of miR-34a mimics shifting the targetome towards HNF4α” on November 29th with Prof. Kotaro Nakanishi from Ohio State University as her opponent. She systematically identifies mir-34a mutants which more efficiently regulate a subset of the original mir-34a targetome, reducing unwanted off-target effects
Congratulations to Katja and visiting Prof. Christina Thiele for your article in Angewandte Chemie on the interaction dynamics of an enantioselective peptide catalyzed acylation reaction!
We are happy to welcome Eleni to our lab as a new research assistant working on the ribosome project!
Congratulations Rubin and Walter for their publication in NAR studying the previously unseen arrangement of key nucleotides in the human Argonaute 2 miRNA-mRNA complex
Congrats Henry and Reiner for their article in JBNMR on optimising in-cell NMR for nucleic acids!
Dr. David Kosek has joined our lab as Postdoctoral Fellow coming from our collaborator Prof. Emma Andersson to continue to share his expertise on microRNA regulation with the lab!
Dr. Sweetapple successfully defended her thesis on 18th of June with her opponent Prof. Qi Zhang from the University of North Carolina! Huge congratulations for a great work, clear presentation and engaging discussion. Her thesis: “A biophysical symphony: the interplay of factors determining microRNA-34a activity” has helped towards deciphering the complicated structural influences on microRNA…
Visiting Professor Snorri Sigurdsson from the University of Iceland is now returning home after a great time with us. We want to thank him for his good humour, expertise, and contributions to our lab discussions – with an exciting collaboration which made significant steps during his stay. Furthermore, a big goodbye and thank you to…
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Petzold lab at Uppsala University
Petzold lab at Karolinska Institutet
Petzold lab at BMC (D9:3)
Uppsala University
Department of Medical BIochemistry and Microbiology (IMBIM)
Husargatan 3
752 37 Uppsala
Sweden
Katja Petzold
Uppsala University, BMC D9:3
IMBIM
Husargatan 3
752 37 Uppsala
Sweden