Our research group is interested in understanding how RNAs change their structures in order to perform function. Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.
Christian Steinmetzger, who did his PhD in the lab of Claudia Höbartner and Natalia Galindo Riera, who did her PhD in the lab of Isabel Martinez Garay, join as Postdoctoral Fellows the lab. Cenk Onur Gürdap comes back and works with us part-time while pursuing a Master degree at KTH.
Please apply via the online system varbi. Join a diverse team having fun doing RNA structural biology/biophysics in vitro and in the cell.
On Thursday the 30th of July at 4pm CET, Katja will present our research at the webinar organized by ICMRBS & Euromar “Emerging Topics in Biomolecular Magnetic Resonance”. This will be later also available on the youtube channel and is organized by L. Andreas, S. Glöggler, C. Griesinger, M. Hong, O. Millet, A. Palmer and M. Zweckstetter.
Oligonucleotide Therapeutics Society (OTS) has selected our paper on miR-34a dynamics for paper of the month in May Thank you and big congrats to Lorenzo!
François Major writes “From transient recognition to efficient silencing: a RISCky business” in NSMB. Fabulous!
Our paper on how miR-34a influences the activity of Sirt1 (regulator of P53) is published in Nature. Congratulations to Lorenzo, first author of the study, and of course everyone else.
Postdoctoral fellow Sarah Friebe Sandoz finishes her postdoc
in the Petzold lab and leaves for a position in a start up company.
We wish you good luck and we will miss you.
Congratulations Hampus to the acceptance of His manuscript A robust and versatile method for production and purification of large-scale RNA samples for structural biology in the journal RNA.
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Mail:
Department of Medical Biochemistry and Biophysics (MBB)
Box 23 109 Karolinska Institute SE-104 35
Stockholm, Sweden
Biomedicum:
Petzold Lab Quarter 9B, Dept. of Medical Biochemistry and Biophysics
Solnavägen 9
171 65 Solna
NMR lab:
SciLifeLab Karolinska Institutet
Tomtebodavägen 23b
171 65 Solna
