François Major writes “From transient recognition to efficient silencing: a RISCky business” in NSMB. Fabulous!
Our research group is interested in understanding how RNAs change their structures in order to perform function. Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.
Our paper on how miR-34a influences the activity of Sirt1 (regulator of P53) is published in Nature. Congratulations to Lorenzo, first author of the study, and of course everyone else.
Postdoctoral fellow Sarah Friebe Sandoz finishes her postdoc
in the Petzold lab and leaves for a position in a start up company.
We wish you good luck and we will miss you.
Congratulations Hampus to the acceptance of His manuscript A robust and versatile method for production and purification of large-scale RNA samples for structural biology in the journal RNA.
WFH and NMR – team work in trying times: Judith, Hampus and Luca with help from Clara. Stay safe and wash hands!
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Department of Medical Biochemistry and Biophysics (MBB)
Box 23 109 Karolinska Institute SE-104 35
Petzold Lab Quarter 9B, Dept. of Medical Biochemistry and Biophysics
171 65 Solna
SciLifeLab Karolinska Institutet
171 65 Solna