In-cell NMR in ChemBioChem
Our paper “Observing an antisense drug complex in intact human cells by in-cell NMR” has been accepted by ChemBioChem – read exciting work on how to detect unmodified NA in intact human cells using DNP and NMR.
Our research group is interested in understanding how RNAs change their structures in order to perform function. Until recently, only snapshots of molecules could be observed, hiding their mode of operation. We employ Nuclear Magnetic Resonance (NMR), and other biophysical techniques, to investigate the molecular mechanism of RNA function. When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab develops methods in NMR and RNA biochemistry to address these questions. Current projects include viral, bacterial and eukaryotic regulatory RNAs, e.g. microRNAs, ribosomal RNAs or RNA from HBV.
News
Welcome Magdalena!
Magdalena Riad is our newest PhD candidate working on the ribosome project.
Welcome Elnaz!
Elnaz BaniJamali is our newest PostDoc working on miRNA targeting.
Katja is elected GRC 2023 chair
Katja has been elected the chair of the Computational Aspects of Biomolecular NMR Gordon Research conference for 2023, which means she will also be co-chair in 2021, together with Art Palmer. We are looking forward to exciting meetings to come!
Welcome Cenk!
Cenk Onur Gürdap will work on new methods to produce isotope-labeled RNA with Hannes as a summer student.
Welcome Mahsan
Mahsan Banijamali joined the lab working on miRNA targeting.
Contact:
Email: katja.petzold@ki.se Mail: Department of Medical Biochemistry and Biophysics (MBB) Box 23 109 Karolinska Institute SE-104 35 Stockholm, Sweden
Delivery/visit:
Biomedicum: Petzold Lab Quarter 9B, Dept. of Medical Biochemistry and Biophysics Solnavägen 9 171 65 Solna NMR lab: SciLifeLab Karolinska Institutet Tomtebodavägen 23b 171 65 Solna
